Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells.

نویسندگان

  • Kenji Ohguchi
  • Minako Koike
  • Yoshihide Suwa
  • Seiichi Koshimizu
  • Yuki Mizutani
  • Yoshinori Nozawa
  • Yukihiro Akao
چکیده

We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.

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عنوان ژورنال:
  • Bioscience, biotechnology, and biochemistry

دوره 72 4  شماره 

صفحات  -

تاریخ انتشار 2008